Study of Pseudoternary Phase Diagram Behaviour and the Effect of Several Tweens and Spans on Palm Oil Esters Characteristics

Authors

  • Muthanna F. Abdulkarim School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Penang, Malaysia
  • Ghassan Z. Abdullah School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Penang, Malaysia
  • M.H.F. Sakeena School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Penang, Malaysia
  • Mallikarjun Chitneni1 School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Penang, Malaysia.
  • Mun F. Yam School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Penang, Malaysia.
  • Elrashid S. Mahdi School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Penang, Malaysia.
  • Ibrahim M. Salman School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Penang, Malaysia.
  • Omar Z. Ameer School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Penang, Malaysia.
  • Munavvar A. Sattar School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Penang, Malaysia.
  • Mahiran Basri Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
  • Azmin M. Noor School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Penang, Malaysia

Keywords:

palm oil esters, Tween, Span, Pseudoternary phase diagram, O/W emulsion

Abstract

Palm oil esters are high molecular weight esters oil that has been newly synthesized by University Putra Malaysia researchers. It has received a lot of attention for its pharmaceutical and chemical application. The aim of this study is to study the effects of the palm oil esters with different HLB surfactant mixture on the ternary diagrams behaviour and to confine the various systems resulted from these combinations. These systems include traditional emulsion, gel area, transpernat micro-emulsion area, O/W and W/O emulsions. In this study, pseudoternary phase diagrams of water, POEs and non-ionic surfactant mixture of several HLB values were constructed using water titration method. The resultant mixtures collected after each addition and mixing of water were analysed visually, along with conductivity, dilution in water and dye test (methylene blue) to classify them as O/W emulsion (transparent and opaque) or W/O (opaque) and liquid or gel. As a conclusion, palm oil esters were found to be suitable for the formulation of different types of emulsion. Additionally, different HLB value of non-ionic surfactant(s) exhibited different pseudoternary phase diagram characteristics.

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Published

2011-03-31

How to Cite

Muthanna F. Abdulkarim, Ghassan Z. Abdullah, M.H.F. Sakeena, Mallikarjun Chitneni1, Mun F. Yam, Elrashid S. Mahdi, Ibrahim M. Salman, Omar Z. Ameer, Munavvar A. Sattar, Mahiran Basri, & Azmin M. Noor. (2011). Study of Pseudoternary Phase Diagram Behaviour and the Effect of Several Tweens and Spans on Palm Oil Esters Characteristics. International Journal of Drug Delivery, 3(1), 95–100. Retrieved from https://ijdd.arjournals.org/index.php/ijdd/article/view/59

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Original Research Articles