Stability studies of nano-cream containing piroxicam
Keywords:
Palm oil esters, Nonionic surfactant, Piroxicam, Nano-creamAbstract
The aim of this study is to study the stability of the nano-cream formula containing the newly synthesized palm oil esters when stored for reasonable storage duration. The prepared 0.5% piroxicam nano-cream formula contained phosphate buffer as external phase, palm oil esters as the oil phase and a combination of (80:20) of Tween 80 and Span 20 as emulsifier at a ratio of 37:25:38, respectively. Piroxicam is a hydro-lipophobic drug. Stability on storage is an important aspect which ensures the dosage form can exert the effects it is supposed to exert for the duration of storage. Droplets size, electrical conductivity, drug content, pH and rheological parameters are the parameters that have been assessed under different temperature to evaluate the stability of nano-cream preparation. Thus, experiments which measure the above parameters were conducted at storage temperatures of 4, 25 and 40οC.The data obtained from the stability study conducted on nanocream formula showed that this formulation was stable for the whole 3 months period of the study when stored at tested several temperatures.
References
Petsev, D., Denkov, N. & Kralchevsky, P.
Flocculation of deformable emulsion droplets.
Journal of Colloid and Interface Science 1995;
: 201-213.
Kabalnov, A.S., & Wennerstrom, H.
Macroemulsion stability: The oriented wedge
theory revisited. Langmuir 1996; 12: 276-292.
Taylor, P. Ostwald ripening in emulsions. Adv
Colloid Interfac 1998; 75: 107-163.
Liu, W., Sun, D., Li, C., Liu, Q. & Xu, J.
Formation and stability of paraffin oil-in-water
nano-emulsions prepared by the emulsion
inversion point method. J. Colloid Interface Sci
; 303: 557-563.
Nazarenko, V., Nych, A. & Lev, B. Crystal
structure in nematic emulsion. Phys RevLetters
;87: 75504-75508.
Badolato, G.G., Aguilar, F., Schuchmann, H.P.,
Sobisch, T. & Lerche, D. Evaluation of long term
stability of model emulsions by multisample
analytical centrifugation. Prog Colloid Poly Sci
;134: 66-73.
Mihalic, M. Piroxicam. Analytl Prof Dr Sub
;15: 23.
Jinno, J., Oh, D.-M., Crison, J.R. & Amidon, G.L.
Dissolution of ionizable water-insoluble drugs:
The combined effect of pH and surfactant. J
Pharmaceut Sci 2000;89: 268-274.
Ahmad, K., Ho, C., Fong, W. & Toji, D.
Properties of palm oil-in-water emulsions
stabilized by nonionic emulsifiers. J. Colloid
Interface Sci 1996;181: 595-604.
Desmet, Y., Deriemaeker, L. & Finsy, R. Ostwald
ripening of alkan emulsions in the presence of
surfactant micelles. Langmuir. 1999; 15; 6745-
Keng., P.S., Basria., M., Zakaria, M.R.S., Abdul
Rahman, M.B., Ariff, A.B., Abdul Rahman,
R.N.Z. & Salleh, A.B. Newly synthesized palm
esters for cosmetics industry. Indus Cr Pro
;29: 37–44.
Huang, X., Kakuda, Y. & Cui, W. Hydrocolloids
in emulsions: Particle size distribution and
interfacial activity. Food Hydrocolloids. 2001; 15:
-542.
Nacu, J.A. Behavior of soybean oil-in-water
emulsion stabilized by nonionic surfactant.
Journal Colloid Interface Sci 2003;259: 374-381.
Jin, G., Kan, J., Zhu, Y., Lei, N. & Chen, B.
Spectrophotometric determination of the total
amount of rare-earth after solid–liquid extractive
preconcentration with polyvinyl alcohol
condensed p-formylchlorophosphonazo.
Microchemical Journal 2000;64: 111-118.
Shakeel, F., Baboota, S., Ahuja, A., Ali, J., Faisal,
M. S. & Shafiq, S. Stability evaluation of
celecoxib nano-emulsion containing Tween 80.
Thai J Pharmac 2008;32:4-9.
