Honey gel and film for burn wound
Keywords:
Honey, gel, film, PVA, glycerinAbstract
Honey has been used to treat infected wounds since ancient times. Antibacterial properties of honey are derived from the high sugar content which inhibits bacteria. The natural acidity of honey will inhibit many pathogens. Honey also containing glucose oxidase enzyme that produced hydrogen peroxide when diluted. But honey is still used directly to treat the wound. In this study, we try to formulate the honey to form gel and film. Polymers used are natrium carboxymethyl cellulose (NaCMC), Aqupec 505 HV, hydroxylpropyl methylcellulose (HPMC), gelatine and polyvinyl alcohol (PVA). Selected polymer was formulated into honey film. Polymers should be combined with plasticizer to improve their properties. Plasticizers studied are polyethylene glycol 400, glycerin and propylene glycol. Evaluations for gel including general appearance, homogeneity, pH and spreadability test, washed test and skin irritation test. Film evaluations are thickness, tensile strength, elongation at break, YoungÊs modulus and water vapour permeability. Based on general appearance and physical properties of gel and film, formula that used PVA as polymer and glycerin as plasticizer is the best formula in this study.
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