Taste masking of Metoclopramide Hydrochloride by Novel Melt Granulation
Keywords:
Metoclopramide HCl, Glycerol monostearate, Melt granulation, Taste maskingAbstract
The purpose of this research was to mask the intensely bitter taste of metoclopramide HCl by complexation with glycerol monostearate. Drug- glycerol monostearate complex was prepared by melt granulation technique in the ratio of 1:1, 1:2, 1:3,1:4. The optimum drug: glycerol monostearate ratio required for complexation was determined. The drug: glycerol monostearate complex were evaluated for the drug content, in-vivo, in-vitro taste evaluation study. The complex was characterized by FTIR, differential scanning calorimetry. The taste evaluation depicted the successful taste masking of metoclopramide HCl with drug: glycerol monostearate 1:4 ratio.
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