Formulation and Characterization of Fexofenadine hydrochloride Fast Dissolving Tablet by using various Superdisintegrants
Keywords:
Fexofenadine hydrochloride, fast dissolving tablets, crosscarmellose sodium, crospovidone, kyron T-314Abstract
In the present work, fast dissolving tablets of fexofenadine HCl were designed with a view to enhance patient compliance by direct compression method. The present work studied the effect of superdisintegrants on release rate of fexofenadine HCl in the form of fast disintegrating tablet. For the present study range of superdisintegrants in their different concentrations, were used. The superdisintegrants used were crosscarmellose sodium, crosspovidone and kyron T-314. The blends were prepared by direct compression technique. The tablets were evaluated for hardness, thickness, friability, drug content, weight variation and in-vitro drug release studies in pH 6.8.
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