Development and in- vitro evaluation of buccoadhesive Tablets of losartan potassium
Keywords:
Losartan potassium, Buccoadhesive, Carbopol 934P, Sustained releaseAbstract
The buccoadhesive controlled release tablets of Losartan potassium were prepared by Wet granulation method using the Carbopol 934P, hydroxy propyl cellulose (HPC), sodium alginate and sodium CMC as bioadhesive polymer. The tablets were evaluated for the Precompression Parameters and post compression parameter like bioadhesive strength, In vitro retention time, and In vitro drug release study. The thickness and weight of the tablets, respectively, ranges from 2.3 ± 0.01 and 2.5 ± 0.02 and the weight of tablets ranges from 148-152mg.The Formulation containing sodium CMC and Sodium alginate shows acceptable bioadhesive strength but erode respectively, with in 6 to 8 hours. The tablet formulation containing carbopol and HPC shows higher bioadhesive strength, sustained release of drug and sufficient In vitro retention time. The optimized formulation obeys the first order release kinetics.
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