Spectrophotometric method development and validation of itopride hydrochloride in bulk and dosage form

Authors

  • Santosh U. Zate Department of Pharmaceutics, MVPS’s College of Pharmacy, Shivajinagar, Gangapur Road, Nashik-422002, Maharashtra, India.
  • Paresh I. Kothawade Department of Pharmaceutics, MVPS’s College of Pharmacy, Shivajinagar, Gangapur Road, Nashik-422002, Maharashtra, India.
  • Jitendra W Gajbe Department of Pharmaceutics, MVPS’s College of Pharmacy, Shivajinagar, Gangapur Road, Nashik-422002, Maharashtra, India.
  • Anantwar S. Pramod Department of Pharmaceutics, MVPS’s College of Pharmacy, Shivajinagar, Gangapur Road, Nashik-422002, Maharashtra, India.
  • Sahebrao S. Boraste Department of Pharmaceutics, MVPS’s College of Pharmacy, Shivajinagar, Gangapur Road, Nashik-422002, Maharashtra, India.

Keywords:

Spectrophotometric, Itopride hydrochloride, Validation

Abstract

A simple, precise and economical spectrophotometric method for the estimation of Itopride hydrochloride in pharmaceutical bulk and tablet dosage form was developed and validated. Identification was carried out using a UVvisible double beam spectrophotometer detector with working wavelength at 258nm in 0.1N HCl medium. The method was validated with respect to its specificity, linearity range, accuracy, and precision in analytical media. Itopride hydrochloride show the maximum absorbance (λmax) at 258 nm, Regression analysis showed good correlation in the concentration range 5- 100 mcg/ml and 96.80 to 106.84% recovery with relative standard deviation 0.293 to 3.98%. Statistical treatment of data reflects that the proposed method is precise, accurate and easily applicable for determination of Itopride hydrochloride in bulk and pharmaceutical preparation.

References

Gupta S, Kapoor V, Kapoor B. Itopride: A Novel

Prokinetic Agent. J K Sci 2004; 6: 106-108.

Yong SK. Effect of itopride, a new prokinetic, in

patients with mild GERD: A pilot study World J

Gastroenterol 2005; 11: 4210-4214.

Hasse A. Severe gastroparesis: New treatment

alternatives. Best Pract Research Clinical

Gastroenterology. 2007; 21: 645–655.

Anirbandeep B. LC–MS Simultaneous

Determination of Itopride Hydrochloride and

Domperidone in Human Plasma.

Chromatographia 2009; 69: 1-9.

Dighe VV. High-performance thin-layer

chromatographic determination of itopride

hydrochloride in its pharmaceutical preparation

and in the bulk drug. JPC 2007; 19: 319-323.

Choudhary B. New visible Spectrophotometric

method for estimation of Itopride hydrochloride

from tablets formulations using methyl orange

reagent. IJPPS 2009; 1: 59-162.

Misra M, Misra A, Panpalia G. Development and

Validation of Spectrophotometric Method for

Estimation of Pefloxacin Mesilate in bulk and its

dosage Form. Pharmabit Int. J 2008; 18: 108-114.

Downloads

Published

2010-12-31

How to Cite

Santosh U. Zate, Paresh I. Kothawade, Jitendra W Gajbe, Anantwar S. Pramod, & Sahebrao S. Boraste. (2010). Spectrophotometric method development and validation of itopride hydrochloride in bulk and dosage form. International Journal of Drug Delivery, 2(4), 340–343. Retrieved from https://ijdd.arjournals.org/index.php/ijdd/article/view/47

Issue

Vol. 2 No. 4 (2010): Oct-Dec

Section

Original Research Articles

Most read articles by the same author(s)