Current Aspects and Therapies for Wound healing

Authors

  • Harvinder Popli Delhi Pharmaceutical Sciences, Department of Pharmaceutics, Research University, New Delhi, India
  • Reena Badhwar Delhi Pharmaceutical Sciences, Department of Pharmaceutics, Research University, New Delhi, India

Keywords:

Non healing wounds and ulcer, current challenges, mechanism, cytokines, growth factors

Abstract

Injury to the skin provides a new challenge, as wound healing is a complex and intricate process. Nonhealing wounds represent a significant cause of morbidity and mortality for a large portion of the population. Delayed wound healing is one of the major therapeutic and economic issues in medicine today. Wound healing requires a concerted effort of remodeling of various components of the connective tissue in the presence of appropriate cytokines and growth factors. Unfortunately we still do not understand the actual mechanism of wound healing. This review is an effort to provide information about current challenges of wound healing and their management, recent advances in wound care technology and current management guidelines for the treatment of wounds and ulcers. Various steps like microbial control, subsidence of inflammation, regeneration of connective tissue, angiogenesis and epithelialisation should take place in a time-bound sequence. The development of new and effective interventions in Wound care remains an area of intense research

References

Eming SA, Krieg T, M J. Davidson: Inflammation in

Wound Repair Molecular and Cellular Mechanisms.. vol.

; 2007.

A DF. Modolo LV, Sanches ACC, Porto RR: Wound healing agents, the role of natural and non-natural products in

drug development. Mini Rev Med Chem. 2008;8:879–88.

Strauss MB, Miller MS, Aksenov MV. Challenges of

wound healing. Challenges of; 2011.

Menke NB, Ward KR, Witten TM. Bonchev DG, Diegelmann RF: Impaired wound healing. Clin. Dermatol; 2007.

Cheng CF, D. Sahu: To accelerate effectively both acute

and diabetic wound healing in mice,”. The Journal of Clinical Investigation. 2011;121(11):4348–4361.

Agale SV. Chronic Leg Ulcers: Epidemiology, Aetiopathogenesis, and Management. Hindawi Publishing Corporation Ulcers; 2013.

Langer V. Leg ulcers, An Indian perspective. Indian Dermatol Online J. 2014;5(4):535.

Shukla VK, Ansari MA, Gupta SK. Wound healing research: A perspective from India. Int. J Low Extreme

Wounds. 2005;4:7–8.

Strauss MB. Challenges of wound healing; 2010. .

Nedelec B, Oliveira AD, Saint-Cyr M. Garrel D: Differential effect of burn injury on fibroblasts from wounds and

normal skin; Plast. Reconstr Surg. 2007;119:2101–9.

Yukami T, Hasegawa M, Matsushita Y, Fujita T, Matsushita T, Horikawa M. et al.: Endothelial selectins regulate skin wound healing in cooperation with L-selectin and

ICAM-1. J Leukoc Biol. 2007;82:519–31.

Mosser DM, Edwards. JP: Exploring the full spectrum of

macrophage activation. Nat. Rev Immunol. 2008;8:958–

Bradshaw AD, Reed MJ, Sage. EA: SPARC-null mice exhibit accelerated cutaneous wound closure. J Histochem

Cytochem. 2002;50:1–10.

Fathke C, Wilson L, Shah K, Kim B, Hocking A, Moon

R. Wnt: signaling induces epithelial differentiation during

cutaneous wound healing. BMC Cell Biol. 2006;7:1017–

Inada R, Matsuki M, Yamada K, Morishima Y, Shen

SC, Kuramoto N. et al: Facilitated wound healing by

activation of the transglutaminase gene. Am J Pathol.

;157:1875–82.

Dissemond J, Witthoff M, Brauns T, Haberer D. pH Value

of chronic wound milieu. Hautarzt; 2003.

Vuotila T, Ylikontiola L, Sorsa T, Luoto H, Hanemaaijer R,

Salo T. The relationship between MMPs and pH in whole

saliva of radiated head and neck cancer patients. J Oral

Pathol Med. 2002;31:329–38.

Baker EA, Leaper DJ. Proteinases, their inhibitors, and cytokine profiles in acute wound fluid. Wound Repair Regen.

;8:392–8.

Jansen P, Rosch R, Jansen M, M B, Junge K, AlfonsoJaume A. Regulation of MMP-2 gene transcription in dermal wounds. J Invest Dermatol. 2007;127:1762–7.

Kuwahara M, Tada H, Mashiba K. Mortality and recurrence rate after pressure ulcer operation for elderly longterm bedridden patients. Ann Plast Surg;2005(54):629–32.

Nunan1 R, Martin KGHP. Clinical challenges of

chronic wounds, searching for an optimal animal model

to recapitulate their complexity. Disease Models &

Mechanisms;2014(7):1205–1213.

Robson MC. Wound infection: a failure of wound healing

caused by an imbalance of bacteria. Surg Clin North Am.

;77:637–50.

Brooks PC, Clark RAF. Cheresh DA: Requirement of vascular integrin avb for angiogenesis Science; 1994.

Blair RJ, Meng H, Marchese MJ, Ren S, Schwartz LB,

Tonnesen MG, et al. BL: Human mast cells stimulate vascular tube formation Tryptase is a novel, potentangiogenic

factor. J Clin Invest;1997(99):2691–2700.

Tonnesen MG, Feng X, Clark RAF. Angiogenesis

in Wound Healing. J of Investigative Dermatology.

;5:40–46.

Wright JB, Lam K, Burrell BRE. PhD: Wound management in the era of increasing bacterial antibiotics resistance, a role for topical silver treatment; 1998.

Leaper DJ. Prophylactic and therapeutic role of antibiotics

in wound care. Am J Surg. 1994;p. 1–15.

Howell-Jones RS, Wilson MJ, Hill KE, Howard AJ, Price

PE, Thomas DW. A review of the microbiology, antibiotic

usage and resistance in chronic skin wounds. Journal of

Antimicrobial Chemotherapy. 2005;55:143–149.

Farrerasa N, Vicenc-Artigasb, Cardonac D, Riusb X, Triasb M, A J. Gonza, leza: Effect of early postoperative

enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer. Clinical Nutrition.

;24:55–65.

N ASMJ. Mansbridge: The Innate Immune System in

Acute and Chronic Wounds. Advances in wound care;

Park JE, D AM. Barbul, M.D: Understanding the role of

immune regulation in wound healing. The American Journal of Surgery. 2004;187:11–16.

Barbul A. Immune aspects of wound repair: Clin Plast

Surg; 1990.

Cooper R. Understanding wound infection. In European

Wound Management Association (EWMA). Position Document: Identifying criteria for wound infection; 2005.

Zafran SZEN, Garmi G. Raed Salim: Postcesarean

wound infection, prevalence, impact, prevention, and management challenges. International Journal of Women’s

Health;2017(9):81–88.

Cutting K, White RJ, Mahoney P. Harding KG: Clinical

identification of wound infection, a Delphi approach. In.

European Wound Management Association (EWMA) Position. 2005;p. 6–9.

White RJ: Wound infection-associated pain. J Wound

Care. 2009;18(6):245–49.

Cutting KF. Harding KG: Criteria for identifying wound

infection. J Wound Care. 1994;3(4):198–201.

Ayello EA, Dowsett C, Schultz. GS: Time heals all

wounds. Nursing. vol. 34; 2004.

Viswanathan PV. FRCP (London), FRCP (Glasgow): Epidemiology of Diabetic Foot and Management of Foot

Problems in India. The International Journal of Lower Extremity Wounds;9(3):122–126.

Steed DL. Debridement. Am J Surg. 2004;187:71–4.

Bergstrom N, Bennett MA, Carlson CE. Treatment of Pressure Ulcers: Clinical practice guidance; 1994.

West JM. Wound healing in the surgical patient: influence

of the perioperative stress response on perfusion; 1990.

Professor of Wound Healing and Director Wound Healing

Research. Journal of. 2000;9.

Kranke P, Bennett M. Roeckl Wiedmann I, Debus S: Hyperbaric oxygen therapy for chronic wounds. Cochrane

Database Syst Rev; 2004.

Cronje FJ. Oxygen therapy and wound healing—topical

oxygen is not hyperbaric oxygen therapy. S Afr Med

J;2005(95):840.

Armstrong DG, Lavery. LA: Negative pressure wound

therapy after partial diabetic foot amputation. A multicenter randomized controlled trial. Lancet; 2005.

Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt.

W: Vacuum-assisted closure, A new method for wound

control and treatment, Animal studies and basic foundation. vol. 38. Ann Plast: Surg; 1997.

Shirin Garg: Role of Negative Pressure Wound Therapy

in Healing of Diabetic Foot Ulcers. J Surg Tech Case

Rep2011;3(1):17–2.

Piantadosi CA: Topical oxygen is not hyperbaric oxygen

(HBO2). Undersea Hyperb Med; 2003.

Hunt TK, Zederfeldt B. Goldstick TK: Oxygen and healing. Am J Surg. 1969;118:521–525.

Samil Aktas, MDd: Topical Oxygen for Chronic Wounds:

A PRO/CON Debate. Journal of the American College of

Clinical Wound Specialists;2015(5):61–5.

Winter GD. Epidermal regeneration studied in the domestic pig. Chicago: Year Book Medical Publishers; 1972. p.

–112.

Bolton L, McNees P, Rijswijk L, Leon J, Lyder C, Kobza.

L: Wound-healing outcomes using standardized assessment and care in clinical practice. J Wound Ostomy Continence Nurs;2004(31):65–71.

Rovee DT. Evolution of wound dressings and their effects

on the healing process. Clin Mater; 1991.

Kannon GA, Garrett. AB: Moist wound healing with occlusive dressings: a clinical review. Dermatol Surg; 1995.

Alvarez OM, Mertz. PM, Eaglstein WH: The effect of occlusive dressings on collagen synthesis and

re-epithelialization in superficial wounds. J Surg

Res1983;35:142–8.

Baker PD. Creating the optimal environment: an overview

of dressings for chronic wounds. Adv Nurse Pract; 2005.

Jones V, Milton T. When and how to use hydrogels. Nurs

Times. 2000;96:3–4.

Motta G, Dunham L, Dye T, Mentz J, O’Connell-Gifford

E, Smith. E: Clinical efficacy and cost-effectiveness of

a new synthetic polymer sheet wound dressing. Ostomy

Wound Manage1999;45:41–9.

Kaya AZ, Turani N. Akyuz M: The effectiveness of a hydrogel dressing compared with standard management of

pressure ulcers. J Wound Care. 2005;14:42–4.

Szycher M, Lee. SJ: Modern wound dressings, a systematic approach to wound healing. J Biomater Appl.

;7:142–213.

Hess CT. Wound care. Baltimore, MD: Lippincott

Williams and Wilkins; 2005.

Ohura N, Ichioka S, Nakatsuka T, Shibata. M: Evaluating

dressing materials for the prevention of shear force in the

treatment of pressure ulcers. J Wound Care. 2005;14:401–

Banks V, Hagelstein S, Thomas N, Bale S, KG H. Comparing hydrocolloid dressings in management of exuding

wounds. Br J Nurs. 1999;1999(8):640–6.

Pirone LA, Bolton LL, Monte KA, Shannon. RJ: Effect of

calcium alginate dressings on partial-thickness wounds in

swine. J Invest Surg. 1992;5:149–53.

Taylor BA. Selecting wound healing products: choices for

long-term care settings. Adv Nurse Pract; 2003.

Segal HC, Hunt. BJ, Gilding K: The effects of alginate

and nonalginate wound dressings on blood coagulation and

platelet activation. J Biomater Appl1998;12:249–57.

Fletcher J. Understanding wound dressings: foam dressings. Nurs Times. 2005;101:50–1.

Eaglstein WH, Mertz PM, Falanga V. Occlusive dressings.

Am. vol. 35. Fam Physician; 1987.

Twinsburg. Ohio Edgepark Surgical Catalog ; 2005.

Thomas S, McCubbin P. A: comparison of the antimicrobial effects of four silver-containing dressings on three organisms. J Wound Care. 2003;12:101–7.

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Published

2018-06-30

How to Cite

Harvinder Popli, & Reena Badhwar. (2018). Current Aspects and Therapies for Wound healing. International Journal of Drug Delivery, 10(2), 1–10. Retrieved from https://ijdd.arjournals.org/index.php/ijdd/article/view/320

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Review Article