Formulation and evaluation of once a day matrix tablets of Valsartan
Keywords:
valsartan, FT-IR studies, Caco-2, permeability, absorption enhancementAbstract
The objective of the research investigation was to design and evaluate the oral once a day matrix tablets of valsartan by using various natural matrix former gums such as separately. Initially natural gums are extracted and purified and their extracts are evaluated for their proximate phyto-chemical studies. Tablets were prepared by wet granulation method. The prepared tablets were further evaluated for physical parameters, In-vitro dissolution, and drug-excipients interactions are also carried out. The FT-IR studies revealed that there was no chemical interaction between drug and excipients. Among all prepared formulations, formulation F-8 exhibited precise controlled release of drug over a prolonged period of 24 hrs. The in- vitro dissolution data obtained for various formulations were fitted into zero order, first order, Higuchi’s and Korsymeyer - Peppas kinetic models. The optimized formulation displayed zero order release kinetics and Korsmeyer and Peppas equation give release pattern with values of (n = 0.9094) indicating non-fickian (or) Anomalous types of diffusion takes place through matrix of Gum Kondagogu. The optimized formulations F-8 was subjected to stability studies for three months at 400C/75%RH as per ICH guidelines and result does not shows any change in physical parameters and in-vitro release studies.
References
. Venkatraman S, Davar N, Chester A, and Weiner L. An Overview of Controlled Release System. In: Handbook of Pharmaceutical Controlled Release Technology. 1st ed., Marcel Dekker, 2000; 435-440.
. Patel Kundan K, Patel Mehul S, Bhatt Nayana M, Patel Laxmanbhai D, Pathak Nimish L and Patel Kanu J. An Overview: Extended Release Matrix Technology. International Journal of Pharmaceutical and Chemical Sciences. 2012;2:828-843.
. Leon Shargel, Susanna Wu-Pong, Andrew BC Yu. Modified-Release Drug Products. In: Applied Biopharmaceutics & Pharmacokinetics, 5th ed., 2004; 60-65.
. Leon Shargel, Susanna Wu-Pong, Andrew BC Yu. Modified-Release Drug Products. In: Applied Biopharmaceutics & Pharmacokinetics, 5thed., 2004;60-78.
. Robinson JR, Lee VHL. Controlled Drug Delivery: Fundamentals and Applications. 2nd ed., New York, Marcel Dekker, Inc.1987.
. D.M. Brahmankar, Sunil B.Jaiswal. Controlled Release Medication. In: Biopharmaceutics and Pharmacokinetics. 2nd ed., Vallabh Prakashan.2009; 399-400.
. Chien YW. Novel drug delivery systems. 2nd ed., New York, Marcel Dekker, Inc. 1992.
. Gwen M. Jantzen and Joseph R. Robinson. Sustained and Controlled Release Drug Delivery System. In: Modern Pharmaceutics, 4th ed., 2002; 503-504.
. Jain NK. Pharmaceutical Product Development. 1st ed., CBS Publishers and Distributors. 2006; 419-424.
. Robinson JR, Lee VHL. Controlled Drug Delivery: Fundamentals and Applications. 2nd Ed., New York: Marcel Decker; 1987:253-260.
. D.M. Brahmankar, Sunil B.Jaiswal. Controlled Release Medication. In: Biopharmaceutics and Pharmacokinetics. 2nd ed., Vallabh Prakashan.2009; 412-430.
. Mahesh Hemnani, Upendra Patel, Ghanshyam Patel, Dhiren Daslaniya, Amarish Shah, Bhavin Bhimani. Matrix Tablets: A Tool of Controlled Drug Delivery. American Journal of Pharmatech Research, 2011;1(4):127-143.
. Gwen M. Jantzen and Joseph R. Robinson. Sustained and Controlled Release Drug Delivery System. In: Modern Pharmaceutics, 4th ed., 2002; 507-510.
. Leon Shargel, Susanna Wu-Pong, Andrew BC Yu. Modified-Release Drug Products. In: Applied Biopharmaceutics & Pharmacokinetics, 5th ed., 2004.
. D.M. Brahmankar, Sunil B.Jaiswal. Controlled Release Medication. In: Biopharmaceutics and Pharmacokinetics. 2nd ed., Vallabh Prakashan.2009;400-406.
. Khyati Patel, Dr.Upendra Patel, Bhavin Bhimani, Ghansyam Patel, Dhiren Daslanyia. Extended Release Oral Drug Delivery System. International journal of Pharmaceutical Research and Bio Sciences, 2012; 1(26):1-26.
. Nicholas G. Sustained Release Dosage Forms. In: The theory and Pratice of Industrial Pharmacy. 3rd ed., Varghese Publishing House. 1987; 430-476.
. Fincher JH. Particle size of drugs and its relation to absorption and activity. Journal of Pharmaceutical Sciences. 1968; 57:1825-1835.
. Chien YW. Controlled and modulated-release drug delivery systems. In: Swarbrick J, Balyan JC. Encyclopedia of Pharmaceutical Technology. New York: Informa Health Care. 1990; 281-313.
. Harnish Patel, Dhrupesh R. Panchal, Upendra Patel, Jushar Brahmbatt, Mayur Suthar. Matrix Type Drug Delivery System: A Review. Journal of Pharmaceutical Sciences Research and Bioscientific Research, 2011; 1(3):143-151.
. Tapaswi RaniDash, Pankaj Verma. Matrix Tablets: An Approach towards Oral Extended Release Drug Delivery. International Journal of Pharma Research and Review, 2013; 2(2):12-24.
. Loyd V. Allen. Jr, Nicholos G, Popvich Howard C. Ansels. Solid Oral Modified-Release Dosage Forms and Drug Delivery System. In: Ansel’s Pharmaceutical Dosage Forms and Drug Delivery System. 9th ed., Wolters Kluwer Health and Lippincott Williams and Wilkins. 2009; 257-270.
. Vinay Kumar, S K Prajapati, Girish C Soni, Mahendra Singh, Neeraj Kumar. Sustained Release Matrix Type Drug Delivery System: A Review. World Journal of Pharmacy and Pharmaceutical Sciences, 2012; 1(3): 934-960.
. John Collett, Chris Moreton. Modified –Release Peoral Dosage Form. In: M.E.Aluton’s Pharmaceutics – The Science of Dosage Form Design. 2nd ed., Churchill Living Stone.2003;297-302.
. D.M. Brahmankar, Sunil B.Jaiswal. Controlled Release Medication. In: Biopharmaceutics and Pharmacokinetics. 2nd ed., Vallabh Prakashan.2009;413-416.
