Two-Photon-Absorption Triggered Release of 5-Fluorouracil from Isomer-Pure Polymer-Bound Syn-Head-to-Head Dimers for Novel Intraocular Lenses

Authors

  • Annegret P. Busch University of Marburg, Department of Chemistry, Hans-Meerwein-St. 4 35032 Marburg, Germany
  • Norbert A. Hampp Material Sciences Center, 35032 Marburg, Germany

Keywords:

Photo-triggered drug release, 5-fluorouracil, isomers, two-photon-absorption, [2 2]-cycloreversion, acrylic polymer

Abstract

Different stereoisomers ofthe cytotoxic 5-fluorouracil (5FU)homodimers were synthesizedby photochemical [2+2]-cycloaddition and polymerized into MMA/HEMA to form a novel drug-loaded copolymer for intraocular lenses as irradiation-activated treatment for secondary cataract. Three isomers were obtained, and showed significant differences in cleavage efficiency on photo-cleavage via single-photon-absorption (SPA)and two-photon-absorption (TPA). The most efficient TPA cleavage rate was observed for the syn-head-to-head 5FU dimer, which was, consequently, used for drug loading of the polymeric material to obtain a drug-loaded material of higher efficiency compared to previous works. The light and thermal stability of the polymer were confirmed and multi-dose release of the drug in aqueous solution for possible repeated treatment of cataract was proven.

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Published

2015-09-30

How to Cite

Annegret P. Busch, & Norbert A. Hampp. (2015). Two-Photon-Absorption Triggered Release of 5-Fluorouracil from Isomer-Pure Polymer-Bound Syn-Head-to-Head Dimers for Novel Intraocular Lenses. International Journal of Drug Delivery, 7(3), 174–190. Retrieved from https://ijdd.arjournals.org/index.php/ijdd/article/view/281

Issue

Vol. 7 No. 3 (2015): Jul- Sep

Section

Original Research Articles