Controlled delivery of Imatinib mesylate from collagen-coated poly (lactic acid) microspheres: In vitro release studies
Keywords:
Collagen coating, biocompatibility, anticancer drug, in vitro releaseAbstract
The development of injectable microspheres for controlled drug delivery to the desired site is a major challenge. We demonstrated the possibility of entrapping an anticancer drug, Imatinib mesylate, in collagen coated biodegradable poly (lactic acid) microspheres with a mean diameter of 10-20 øm. The collagen coating on polymeric matrix surfaces through various surface modification techniques was the current scenario to improve bio-integration of the polymers with the in-vivo system. Here protein adsorption principle is used and various characterization techniques like FTIR, DSC and SEM analysis are used to confirm collagen coating. The reduction in burst release of the Imatinib from the PLA microspheres further confirms its presence and role in controlled release. This collagen coated PLA microspheres may have potential for the targeted delivery of Imatinib mesylate to treat gastrointestinal stromal tumors, chronic myeloid leukemia cancer.
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