Development and statistical optimization of mucoadhesive drug delivery system of famotidine using hibiscus esculentus polysaccharide
Keywords:
Hibiscus esculentus polysaccharide, Mucoadhesive drug delivery system, Mucoadhesive strength, central composite design (CCD), Texture analysis.Abstract
The present study was aimed to formulate and evaluate oral mucoadhesive drug delivery system of purified Hibiscus esculentus L polysaccharide (HEP) using famotidine as model drug. A central composite design for 2 factors at 3 levels each was employed to evaluate the effect of critical variables i.e. concentration of HEP and PVP K30 on drug release and mucoadhesive properties of the formulated tablets. FT-IR spectroscopy and Differential Scanning Calorimetry was carried out to evaluate drug polymer interaction. Formulated tablets were evaluated for physical properties, drug release characteristic and physical stability. Ex-vivo mucoadhesion study using goat gastric mucosa was carried out to ascertain the mucoadhesion potential of formulated tablets. The response surface analysis clearly indicated the dominating effect of HEP on mucoadhesive strength, mucoadhesion time and dissolution half life, while PVP K30 has an additive effect on all afore mentioned responses. The drug release from the matrix tablets was highly affected by the concentration of release retardants polysaccharide. The kinetics of drug release was found to be first order in low concentration but with increase in polymer concentration the release pattern shifted towards zero order and is governed by both Higuchi and Hixson-Crowel equation indicating a coupling effect of diffusion and erosion. The result of the study suggests that, HEP can be optimistically explored as excellent mucoadhesive agent with controlled release characteristics.
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