FORMULATION AND IN VITRO CHARACTERIZATION OF ACECLOFENAC SUSTAINED RELEASE PELLETS PREPARED BY SUSPENSION LAYERING TECHNIQUE USING SUGAR SPHERES

Authors

  • Suresh Kumar Jss college of pharmacy,JSS university India
  • Suggula Sai Ratan Jss college of pharmacy,JSS university India
  • YAkkala Anil Raju Jss college of pharmacy,JSS university India

Keywords:

Aceclofenac, suspension layering, enteric coating, pellets

Abstract

The present work deals with the aceclofenac pellets prepared by suspension layering technique, using sugar spheres with various concentrations of ethyl cellulose and kollicoat SR-30D as enteric coating materials. Prepared pellets were evaluated for physical characteristics which showed excellent flow properties. Formulation F8 with the maximum drug content of 97.17% showed a prolonged in vitro drug release till 10hr when compared with the pure drug. The optimized formulation showed particle size distribution of 546µm.Further stability studies performed according to the ICH guidelines also showed no change in the drug content and property during the shelf life of 3months at prescribed RH and temperature conditions.

References

NA

Published

2014-09-30

How to Cite

Suresh Kumar, Suggula Sai Ratan, & YAkkala Anil Raju. (2014). FORMULATION AND IN VITRO CHARACTERIZATION OF ACECLOFENAC SUSTAINED RELEASE PELLETS PREPARED BY SUSPENSION LAYERING TECHNIQUE USING SUGAR SPHERES. International Journal of Drug Delivery, 6(3), 292–300. Retrieved from https://ijdd.arjournals.org/index.php/ijdd/article/view/254

Issue

Vol. 6 No. 3 (2014): Jul- Sep

Section

Original Research Articles