Chemical Analysis of Gomutra Silasathu Parpam

Authors

  • B. Akila Department of Maruthuvam, National Institute of Siddha, Sanatorium, Chennai-600 047, Tamil Nadu, India.
  • K. Manickavasakam Department of Maruthuvam, National Institute of Siddha, Sanatorium, Chennai-600 047, Tamil Nadu, India
  • R. Shakila Department of Chemistry, Siddha Central Research Institute [CCRS], Arumbakkam, Chennai-600106, Tamil Nadu, India.

Keywords:

Spermatogenic, dhatura, antiepileptic, fulvic acid, gonadotropin, cancer

Abstract

Gomutra Silasathu is one of the ingredients in many herbo-mineral formulations. It tonifies the activity of the seven body constituents (Saptha Thathus) namely plasma, blood, muscle, fat, bone, bone marrow and reproductory fluids of the body. In Siddha system of Medicine, it is used to treat Nabunjagam (Erectyle dysfunction], to improve spermatogenesis, impotence and sexual desire. Silasathu parpam is prescribed for sopana skalitham [Nocturnal emission], megam [Veneral disease], premegam [Gonorrhea], koruku [Contagious ulcers], kiranthi [Glandular swelling]. In the present study Physico chemical analysis and siddha specification for Gomutra silasathu parpam was studied as a step forward to standardization. ICP-OES elemental analysis and the presence of carbon through CHN analysis were studied to support the spermatogenic activity and the therapeutic potential of the medicine.

References

. Rege A, Juvekar P, Juvekar A. In vitro antioxidant and anti-arthritic activities of shilajat. Int J Pharm Pharm Sci. 2012; 4(2): 650-653.

. Wilson E, Rajamanickam GV, Dubey GP, Klose P, Musial F, Saha FJ, Rampp T, Michalsen A, Dobos GJ. Review on shilajit used in traditional Indian medicine. Journal of Ethnopharmacology. 2011; 136: 1-9.

. El-Sayed MIK, Amin HK, Al-Kaf AG. Anti-microbial, anti-oxidant and anti-ulcerogenic effects of Shilajit on gastric ulcer in rats. Am. J. Biochem. & Biotech. 2012; 8 (1): 26-39.

. Nadkarni KM. Indian Materia Medica. 3rd edition. Popular Prakashan Private Ltd Bombay, India. 1954, Vol. 2.

. Pant K, Singh B, Thakur N. Shilajit: A Humic Matter Panacea for Cancer. Int J Toxicol Pharmacol Res. 2012; 4(2): 17-25.

. Anandan AR. Siddha Materica Medica: Mineral And Animal Kingdom. 1st edn, 2008. Department of Indian Medicine and Homoepathy, Arumabakkam, Chennai -106.

. Talbert R. Shilajit : a materia medica monograph. California College of Ayurveda; 1117A East Main Street, Grass Valley, California. 2004.

. Carlos CG, Leonardo G, Ricardo BM. Shilajit : A natural phytocomplex with potential procognitive activity. Int J Alzheimer’s Dis. 2012; 10: 1-4.

. Sharma P, Jha J, Shrinivas V, Dwivedi LK, Suresh P, Sinha M. Shilajit: evalution of its effects on blood chemistry of normal human subjects. Ancient Science of Life. 2003; XXIII(2).

. Biswas TK, Pandit S, Mondal S, Biswas SK, Jana U, Ghosh T, Tripathi PC, Debnath PK, Auddy RG, Auddy B. Clinical evaluation of spermatogenic activity of Processed Shilajit (PS) in oligospermia. Andrologia. 2010; 42(1): 48-56.

. Park JS, Kim GY, Han K. Spermatogenic and ovogenic effects of chronically administered Shilajit to rats. Journal of Ethnopharmacology. 2006; 107: 349-353.

. Chikicha Rathna Deepam. Part-II, Vaidhya Vithvan Kanusamy Pillai. 2007. B. Rathinanayakar & Sons, Chennai-79. p.215.

. Sambasivam Pillai TV. Medical Dictionary-IMHD. Tamil-English of Medicine, Chemist, Botany and Allied science (Based on Medical science); [Department of Indian medicine and Homeopathy]; 2nd edn, 1991, Vol. 2, p.1256.

. Iqbal S, Bhanger MI, Anwar F. Antioxidant properties and components of some commercially available varieties of rice bran in Pakistan. Food Chem. 2005; 93: 265-72.

. Prashith Kekuda TR, Nishanth BC, Praveen Kumar SV, Kamal D, Sandeep M, Megharaj HK. Cow Urine Concentrate : A potent agent with Antimicrobial and Anthelmintic activity. Journal of Pharmacy Research 2010; 3(5): 1025-1027.

. Vats S, Miglani K. Synergistic antimicrobial effect of cow urine and Azadirachta indica on infectious microbes. IJPSR. 2011; 2(7): 1781-1785.

. Dhama K, Chauhan RS, Lokesh S. Anti-cancer activity of cow urine: Current status and future directions. International Journal of Cow Science. 2005; 1(2): 1-25.

. Jain NK, Gupta VB, Garg R, Silawat N. Efficacy of cow urine therapy on various cancer patients in Mandsaur district, India –A survey. International Jouurnal of Green pharmacy. 2010; 4(1): 29-35.

. Jarald E, Edwin S, Tiwari V, Garg R, Toppo E. Antioxidant and Antimicrobial Activities of Cow Urine. Global J Pharmacol. 2008; 2(2): 20-22.

. The Siddha formulary of India; Part-II, First edition [Tamil version] Govt. of India, Ministry of Health and Family Welfare. Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homeopathy [AYUSH], New Delhi. 2011.

. Anonymous. 1998. Quality Control Methods for Medicinal Plant Materials, World Health Organisation, Geneva.

. Anonymous. 2005. Quality control methods for medicinal plants materials. Working document QAS/05.131/Rev.1. World Health Organization, Geneva. pp.27-38.

. ASTM D 422, Standard test method for particle-size analysis of soils ; American Society for Testing Materials, Philadelphia.

. Yunsang Cheah, Wanxi Yang. Functions of essential nutrition for high quality spermatogenesis. Advances in Bioscience and Biotechnology. 2011; 2: 182-197.

. Park JS, Hwang SY, Hwang BY, Han K. The spermatogenic effect of 50% ethanol extracts of yacon and its ameliorative effect against 2,3,7,8-tetrachlorodibenzo-ρ-dioxin induced testicular toxicity in the rat. Natural Product Sciences. 2008; 14(2):73-80.

. Srour SM, Haleem HH, Mahmoud A. Hazard of gossypol on male fertility with trials to overcome the deleterious effects. Egypt. J. Comp. Path. & Clinic. Path. 2009; 22(3): 62-7662.

. Pace AJ, Lee E, Athirakul K, Coffman TM, O’Brien DA, Koller BH. Failure of spermatogenesis in mouse lines deficient in the Na+-K+-2Cl– cotransporter. Koller. J. Clin. Invest. 2000; 105: 441–450.

. Prabu SM, Shagirtha K, Muthumani M. The protective role of S-allylmercaptocysteine against cadmium induced changes in sperm characteristics and testicular oxidative damage in rats. Journal of Pharmacy Research. 2010; 3(11): 2717-1721.

. Ghosal S, Singh SK, Srivastava RS. Shilajit part 2. Biphenyl metabolites from Trifolium repens. J Chem Res. 1988; 196: 165-166.

. Singh SK, Gautam DNS, Kumar M, Rai SB. Synthesis, Characterization and histopathological study of a lead-based indian traditional drug: Naga Bhasma. Indian J Pharm Sci. 2010; 72(1): 24–30.

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Published

2014-03-31

How to Cite

B. Akila, K. Manickavasakam, & R. Shakila. (2014). Chemical Analysis of Gomutra Silasathu Parpam. International Journal of Drug Delivery, 6(1), 88093. Retrieved from https://ijdd.arjournals.org/index.php/ijdd/article/view/232

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Original Research Articles