Synthesis, characterization and antimicrobial activity of novel substituted aryl- 1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine derivatives
Keywords:
1,3,5-triazine, 1,3,4-Oxadiazole, 1,3,4-oxadiazolo-[3,2-a]-1,3, 5-triazine, SchiffÊs base, Antimicrobial activityAbstract
Bioactive heterocyclic rings 1,3,4-oxadiazole and 1,3,5-triazine are fused with expectation of enhanced biological activity of the newly synthesized compounds. Hence Synthesized fused heterocyclic compounds as a substituted aryl- 1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine derivatives The structures of all the compounds were confirmed by physical and spectral analysis. The newly synthesized compounds were evaluated for antimicrobial activity against a variety of bacterial strains and fungal strains. Some of these compounds have shown significant antibacterial and antifungal activity.
References
Gajare AS, Bhawsar SB, Shinde DB and Shingare MS. Synthesis of 2,4-diaryl amino-6-(3,5,6-trichloropyridin-2-yl)oxy triazine and its herbicidal activity. Indian J.chem.1998;37B:510-513.
Sączewski F, Bułakowska A and Bednarski P. Synthesis and anticancer activity of novel 2,4-diamino-1,3,5-triazine derivatives. Eur. J. Med. Chem.,2006;41:219-225.
Sączewski F and Bułakowska A. Synthesis and anticancer activity of novel alkenyl-1,3,5-triazine derivatives. Eur.J.Med.Chem., 2006;41:611-615.
Patel R, Premlata K, Dhanji PR, Chikhalia K. Synthesis and studies of novel 2-(4-cyano-3-tri fluoro methyl phenyl amino) -4 -(quinoline-4-yloxy)-6-(piperazinyl / piperidinyl)-s-triazines as potential antimicrobial, anti-mycobacterial and anticancer agents. Eur.J.Med.Chem., 2011;46:4354-4365.
Mohmmad YW, Abdul RB, Amir A and Fareeda A. Probing the antiamoebic and cytotoxicity potency of novel tetrazole and Triazine derivatives. Eur.J.Med.Chem., 2012;48:313-320.
Arya K and Dandia A. Synthesis and cytotoxic activity of trisubstituted-1,3,5-triazines.Bioorg.med.Chem., 2007;17:3298-3304 .
Yuan-Zhen Xiong, FC, Jan Balzarini, Erik De Clercq. Structural modulation of diaryltriazine with potent anti-HIV activity. Eur.J.Med.Chem., 2008; 43: 1230-1236.
Srinivas K, Srinivas U, Bhanuprakash K, Harakishore K, Murthy USN and Jayathirtha V. Synthesis and antibacterial activity of various substituted s-triazines. Eur.J.Med.Chem., 2006;41: 1240-1246.
Sunduru N, Agarwal A and Katiyar SB. Synthesis of 2,4,6-tri substituted pyrimidine and triazine heterocycles as antileishmanial agents. Bioorg.med.Chem., 2006;14: 7706-7715 .
Geoffrey AM, Reddy R, Francis A, Belley A, Lehoux D, Moeck G. Triaminotriazine DNA helicase inhibitors with antibacterial activity. Bioorg.med.Chem., 2006;16:1286-1290.
Pradip P and Berad B N. Synthesis and antibacterial activity of 1,3,5-thiadiazines and their isomerism into 1,3,5-triazines. Indian J. chem., 2005;44B:638-639.
Solankee A and Patel J. Synthesis of chalcones, pyrazolines, amino pyrimidines and pyrimidinethiones as antibacterial agents. Indian J. chem., 2004;43B:1580-1584.
Gadaginamath GS, Kavali RS and Pujar SR. Synthesis and antibacterial activity of some new 1-n-butyl-3-acetyl-5-(2,4-diamino-1,3,5-triazin-6-yl)methoxy-2-methyl inodole derivatives. Indian J.chem.,1999;38B:1226-1228.
Shelar AR, Adure SA and Shelar MA. Synthesis and antibacterial activity mono aryloxy-s-triazine derivatives of penicillin, cephalosporin, ampicillin and cephalexin. Indian J.chem., 1998;37B:358-364.
Khare RK, Srivastava AK and Singh H. Synthesis and fungicidal activity of some 6-aryl-2-(B-D-glucopyranosyl)-3-oxo-2,3-dihydro-1,3,4-oxadiazolo[3,2-b]-1,2,4,6-thia triazine-1,1-dioxides. Indian J.chem., 2005;44B:163-166.
Indorkar D, Chourasia OP. and Limaye SN. Synthesis, Characterization, Antimicrobial, Antifungal activity of some s-triazine Derivatives of Isoxazoline, Pyrazoline and PC model Computational Studies. Research Journal of Pharmaceutical Science. 2012;1(4):10-16.
Parikh KS and Vyas SP. Synthesis and antimicrobial screening of some new s-Triazine based Piperazine and Piperidine derivatives. Pelagia Research Library
Der Chemica Sinica, 2012;3(2):430-434.
Srivastava AK, Raja SK , Puri SK and Chauhan MS. Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents. Bioorg. med.Chem., 2008;18: 6530-6533.
Agarwal A, Srivastava K, Puri SK and Prem MS. Synthesis of 2,4,6-trisubstituted triazines as antimalarial agents. Bioorg.med.Chem. 2005 Fer;15: 531-535.
Srivastava AK, Raja SK, Siddiqi MI, Puri SK, Sexana JK and Chauhan MS, 4-Anilinoquinoline triazines: A novel class of hybrid antimalarial agents. Eur.J.Med.Chem., 2011;46:676-690.
Shabadi CV, Shelar BA and Shelar AR. New derivatives of isoniazide,pyrazinamide and 2-aminobutanol and their anti-tuberculosis activity. Indian J.chem.1999;38B:508-510.
Basavaraja BM, Vagdevi HM, Srikrishna LP, Shubha BS, Vaidya VP. Synthesis and antimicrobial activity of 1, 3, 4-oxadiazole incorporated benzoxazoles. Indian J Heterocyclic chem. 2008;18:05-08.
Kalluraya B, Jyothi NR, Sujith KV. Microwave assisted one-pot synthesis of some 2, 5-disubstituted 1, 3, 4-oxadiazoles. Indian J Heterocyclic chem.2008;17:359-362.
Nirmala K, Pramilasah K. Synthesis and antibacterial activity of some 2-mercapto-3-phenyl-4-oxa-(3H)-quinazolinyl substituted 1, 3, 4-oxadiazoles. Indian J Heterocyclic chem. 2008; 17: 331-334.
Gaonkar SL, Rai KML, Prabhuswamy B. Synthesis and antimicrobial studies of a new series of 2-(4-(2-(5-ethylpyridin-2-yl)ethoxy)phenyl)-5-substituted-1,3,4-oxadiazoles. Eur J Med. Chem.2006;41:841-846.
Mishra P, Rajak H and Mehta A. Synthesis of Schiff bases of 2-amino-5-aryl-1,3,4-oxadiazoles and their evaluation for antimicrobial activities. J. Gen. Appl. Microbiol., 2005;51:133–141.
Mulwad VV and Chaskar AC. Synthesis and antibacterial activity of new oxadiazolo-[1,3,5]-triazine, 1,2,4 triazolo and thiadiazolo 1.3.4 oxadiazole derivatives. Indian J. chem.,2006;45B:1710-1715.
Pandey VK, Tusi Z and Tandon M. Synthesis of thiadiazolo-s-triazines for their antiviral activity based on QSAR studies. Indian J. chem., 2003;42B:2583-2588.
Murhekar MM, Padghan PD, Mhaskeand SS and Khadsan RE. Synthesis and Antimicrobial activity of new series of s-triazines and its derivatives. Der Phar. chem., 2011;3(6):243-246
Raval JP, Rai AR, Patel NH and Patel HV. Synthesis and in vitro antimicrobial activity of N'-(4-(arylamino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl) benzo hydrazide. Inter. Jour. Chemtech Res., 2009;1(3):616-620.
