Formation, drug-release kinetics and solution-stability of N-acetyl-Ncarboxymethyl chitosan nanoparticles as potential drug carriers
Keywords:
N-acetyl-N-carboxymethyl chitosan, nanoaggregation, nanoparticle, light-scattering (dynamic), stability, controlled releaseAbstract
Nano-aggregates of N-acetyl-N-carboxymethyl chitosan (NCac) were studied at 0.5 mg.mL-1 using pyrene fluorimetry analysis in 0.1 mol.L-1 phosphate buffer (pH 7.4). The size and morphology of the aggregates were determined by dynamic light scattering and atomic force microscopy. The stability of the particles for periods up to 20 h in buffer was determined. Camptothecin was entrapped in the particles using various methods and the rate constant for drug release (k) was determined. Lower k values indicate strong interactions between the drug and the hydrophobic core of the polymeric micelles
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