Biodegradable graft hydrogel membranes for in-vitro release studies of Levofloxacin Hemihydrate drug
Keywords:
Biocompatibility, Poly (Vinyl Alcohol), Methyl Methacrylate, Levofloxine HemihydrateAbstract
Controlled release of Levofloxacin Hemihydrate drug through Methyl Methacrylate grafted Poly (vinyl alcohol) (PVA-g-MMA) hydrogel membranes have been investigated. These graft co-polymer hydrogel membranes of various formulations were prepared using conventional solution casting method by varying, monomer, cross-linker and drug content. An attempt has been made to characterize these hydrogel membranes by various instrumental techniques like, Fourier Transform Infrared Spectroscopy (FT-IR), X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM). The release patterns of the drug from the hydrogel membrane were carried out in pH 7.4 media and the samples were analysed spectrophotometrically at 294 nm wavelength on a UV Vis spectrophotometer. The mechanical properties of the hydrogel membranes were characterized by UTM. FTIR spectra of the membranes indicated complete esterification of the free carboxyl groups of Methyl Methacrylate. XRD studies indicated that the crystallinity of the membranes was mainly due to Methyl Methacrylate. The experimental results indicated that the hydrogel membrane could be tried for various biomedical applications
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