Formulation taste masked orodispersible tablet of Pregabalin
Keywords:
Orodispersible Tablet, Pregabalin, Ion exchange Resin, Kyron T 134Abstract
In the present work, orodispersible tablets of Pregabalin were designed by preparing tasteless complexes of Pregabalin with weak cation ion exchange resins (KYRON T 134). The ion exchange complexes were prepared by the batch process using activated Kyron T 134 with a drug: resin ratios 1:1, 1:2, 1:3 and 1:4 (% w/w). IR analysis, assay content and decomplexation studies confirmed complex formation. It was found that maximum complexation of drug with resin was noted between pH range 5.5-7, while activation of ion exchange resin does not affects the percent drug loading. Drug release from drug: resin complex in salivary pH was insufficient to impart bitter taste. A study on super-disintegrants along with directly compressible diluents is studied and its effect on disintegration time and enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity and in vitro dispersion time. Based on in vitro disintegration time (approximately 30 s), formulations were tested for in vitro drug release pattern (in 0.06 N HCl)
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