Techniques used in orally disintegrating drug delivery system
Keywords:
Orally disintegrating tablet, Superdisintegrant, Patented technologies, Orodispersible tabletsAbstract
Formulation of a convenient dosage form for administration, by considering swallowing difficulty and poor patient compliance, leads to development of orally disintegrating tablets. This are also called as orodisperse, mouth dissolving, rapidly disintegrating, and fast melt system. This disintegrates in the mouth in seconds without chewing and the need of water which is advantageous mainly for pediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. Conventional preparation methods are spray drying, freeze drying, direct compression, Molding, and sublimation while new technologies have been developed for the production of orodispersible tablets. This review depicts conventional and recent technologies that are used to prepare orodispersible tablets in detail.
References
Venkateswara SS, Nyshadham JR, Joseph AF.
Recent technological advances in oral drug delivery
- a review. Pharm. Sci. Tech. Today. 2000; 3: 138-
Porter SC. Novel drug delivery: Review of recent
trends with oral solid dosage forms. Am. Pharm.
Rev., 2001; 85: 28-35.
Bhushan SY, Sambhaji SP, Anant RP, Mahadik
KR. New drug delivery system for elderly, Indian
Drugs 2003; 37: 312-318.
Bandari S, Mittapalli RK, Gannu Rao YM.
Orodispersible tablet: An overview. Asian J.
Pharm. 2008; 2: 2-11.
US Food and Drug Administration, CDER Data
Standards Manual. 2003.
European Pharmacopoeia. 5th ed. Strasbourg,
France: 2006. p. 628.
Avery SW, Dellarosa DM. Approaches to treating
dysphagia in patients with brain injury. Am. J.
Occup. Ther. 1994; 48: 235–239.
Wilson CG. et al. The behavior of a fast dissolving
dosage form (Expidet) followed by g-scintigraphy.
Int. J. Pharm. 1987; 40: 119–123.
Kuchekar BS, Badhan AC, Mahajan HS. Mouth
dissolving tablets: A novel drug delivery system.
Pharma Times 2003; 35: 7-9.
Bradoo R. Fast Dissolving Drug Delivery Systems.
J. Am. Med. Asso. 2001; 4 : 27-31.
O’Connor R, Schwartz J. Extrusion and
spheronization technology. In Pharmaceutical
Pelletization Technology. Marcel Dekker Inc., 37,
p. 187.
Agarwal V, Kothari BH, Moe DV, Khankari RK.
Drug delivery: Fast-dissolve systems. In: Swarbrick
J, Encyclopedia of pharmaceutical technology.
New York, USA: Informa Healthcare Inc.; 2006. p.
–1114.
Fini A, Valentina B, Gian CC, Celestino R, Carlos
A and Fonseca de M. Fast dispersible/slow
releasing ibuprofen tablets. Eur. J. Pharm.
Biopharm. 2008; 69: 335–341.
Masters K. Spray Drying Fundamentals: Process
stages and Layouts. In: Spray Drying Handbook.
th ed. New York, USA: Longman Scientific and
Technical; 1991. p. 23–64.
Hughes L. Selecting the right ion exchange resin.
Pharma Quality 2005; 1: 54–56.
Jeong SH, Park K. Development of sustained
release fast-disintegrating tablets using various
polymer-coated ion-exchange resin complexes. Int.
J. Pharm. 2008; 353: 195–204.
Prasad N, Straus D, Reichart G. Cyclodextrin flavor
delivery systems. US Patent 6,287,603; 1999.
Venkatesh DP, Geetha Rao CG. Formulation of
taste masked orodispersible tablets of ambroxol
hydrochloride. Asian J. Pharm. 2008; 2: 261-264.
Lachman L, Lieberman H, Kanig J. The Theory
and Practice of Industrial Pharmacy. 3rd ed. Lea
and Febige; 1986. p. 420.
Virely P, Yarwood R. Zydis – a novel, fast
dissolving dosage form. Manuf. Chem., 1990, 36–
Seager H. Drug delivery product and the Zydis fastdissolving dosage form. J. Pharm. Pharmacol.
; 50: 375-382.
Ahmed IS, Nafadi MM, Fatahalla FA. Formulation
of fast-dissolving ketoprofen tablet using freezedrying in blisters technique. Drug Dev. Ind. Pharm.
; 32: 437-442.
Allen LV, Wang B, Devies JD. Rapidly dissolving
Tablets. US patent 6,066,337; 2000.
Masaki K. Intrabuccally disintegrating preparation
and production thereof. US patent 5,466,464; 1995.
Dobetti L. Fast-melting tablets: Developments and
technologies. Pharm. Tech. Drug Delivery. 2001;
-50.
Harmon TM. Orally Disintegrating Tablets: A
valuable life cycle management strategy. Issue of
Pharmaceutical Commerce. 2007; 1-4.
Kuno Y, Kojima M, Ando S, Nakagami H. Effect
of preparation method on properties of orally
disintegrating tablets made by phase transition. Int.
J. Pharm. 2008, 355; 87–92.
Abdelbary G, Prinderre P, Eouani C, Joachim J,
Reynier JP, Piccerelle Ph. The preparation of orally
disintegrating tablets using a hydrophilic waxy
binder. Int. J. Pharm. 2004; 278: 423–433.
Perissutti B, Rubessa F, Moneghini M, Voinovich
D. Formulation design of carbamazepine fastrelease tablets prepared by melt granulation
technique. Int. J. Pharm. 2003; 256: 53–63.
Koizumi IK et al. New Method of Preparing Highly
Porous Rapidly saliva Soluble Tablets by
Sublimation Technique. Int. J. Pharm. 1997; 152:
- 131.
Makino T, Yamado M, Kikuta JI. Fast Dissolving
Tablet. US patent 5,720,974; 1998.
Shyamala B, Narmada GV. Rapid dissolving
tablets: A novel dosage form Indian Pharmacist
; 1 : 9-12.
Chiver TE, Minn O. Process for making candy
floss. US patent 730057; 2003.
Bi Y, Sunada H, Yonezawa Y, Danjo K, Otsuka A,
Iida K. Preparation and evaluation of a compressed
tablet rapidly disintegrating in the oral cavity.
Chem. Pharm. Bull. 1996; 44: 2121-2127.
Cousin G, Bruna E, Gendrot E. Rapidly
disintegratagable multiparticular tablet, US patent
,464,632; 1995.
Gillis PMV, Deconde VFV. Fast-dissolving
Galanthamine hydrobromide tablet, US patent
,099,863; 2000.
Gattani SG, Shiyani BG, Kakade KN, Patil AB,
Surana SJ. Formulation and development of mouth
dissolving tablet of Ondensetron hydrochloride by
using superdisintegrants. Indian drugs. 2009; 46:
-50.
Lafon L. Galenic form for oral administration and
its Method of preparation by lyophillization of an
oil-in-water emulsion. Euro. Patent 0,159,237;
Bankar GS, Anderson NR. Tablets. In: Lanchman
L, Lieberman HA, Kanig JL. The Theory and
Practice of Industrial Pharmacy. Lea & Febiger;
p. 293–345.
Wehling F, Schuehle S, Madamala N. Effervescent
dosage form with microparticles. US Patent
,178,878; 1993.
Kaushik D, Dureja S, Saini TR. An overview of
melt in mouth tablet technologies and techniques.
SPI Pharma 2004; 30-35.
Cherukuri SR, Myers GL, Battist GE, Fuisz RC.
Process for forming quickly dispersing comestible
unit and product there from. US Patent 5,587,172;
Fuisz RC. Ulcer prevention method using a meltspun hydrogel. US Patent 5,622,717; 1997.
http://www.elannanocrystal_technology.htm
Liang AC, Chen, Li-Lan H. Fast-dissolving
intraoral drug delivery systems. Expert Opinion
; 11: 981-986.
Verma RK, Garg S. Current Status of Drug
Delivery Technologies and Future Directions.
Pharm. Tech. On-Line 2001; 25: 9–10.
