Topical nanoemulsion of turmeric oil for psoriasis: characterization, ex vivo and in vivo assessment.
Keywords:
Psoriasis, turmeric oil, nanoemulsion, anti-inflammatory, physical stabilityAbstract
Psoriasis is a chronic; T lymphocyte mediated autoimmune inflammatory disorder characterized by well-defined erythematous (reddish) plaques with large adherent silvery scales that affects the skin and other parts of the body. The essential oil in turmeric is antiinflammatory and effective in treating chronic disorders like psoriasis that have inflammation as a root symptom. Nanoemulsions are isotropic, thermodynamically stable transparent (or translucent) systems of oil, water, surfactant and co-surfactant with a droplet size usually in the range of 20–200 nm. Their long-term stability and ease of preparation (spontaneous emulsification) make it promising tool for drug delivery. The aim of this study was to obtain nanoemulsions of turmeric oil for psoriasis and to evaluate their physical stability, irritation potential and in vivo inflammatory activity. For the preparation of nanoemulsion titration method was used which was composed of 15% turmeric oil, 42 % Smix (1:1) and 43 % distilled water. The nanoemulsion was stable during the period of study and was found to be practically non-irritating in the organotypic HET-CAM model. The anti inflammatory activity of optimized nonoemulsion was carried out by carragennen induced paw edema and found to be 70.35 % inhibition.
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