Formulation & Evaluation of Orally Disintegrating Tablet of Ondansetron Hydrochloride
Keywords:
Orally disintegrating tablet, in-vitro disintegration time, wetting time, Ondansetron HCLAbstract
Ondansetron Hcl is a serotonin receptor (5-HT3) antagonist used in the prevention of chemotherapy induced nausea and vomiting. The demand for orally disintegrating tablet has been growing, especially for geriatric and pediatric patients because of swallowing difficulties. In this present study, the bitter taste of Ondansetron Hcl was masked using Tulsion-339 & flavor, also the disintegration time is reduced with using different superdisintegrants . The FTIR studies showed drug and carrier were compatible. These were then compressed into tablets by direct compression method with using different superdisintegrants like Shieffield ODT, Crosspovidone, Pharmaburst- 500, Polyplasdone XL-10, Ludiflash. All formulations were evaluated for disintegration time, wetting time, weight variation, percentage friability and in vitro dissolution rate. Formulations F-02 showed disintegration time below 12 sec, wetting time below 10 sec, containing superdisintegrant ShieffieldODT & Crosspovidone, also shows good sweet taste with no after bitter taste with using tulsion-339 & orange flavour. In vitro dissolution studies of formulations F02 showed more than 95% drug release within 10 minutes. In vitro release profile, disintegration time and wetting time were remaining unchanged after one month when stored at 40ĈC / 75% RH.
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