Preparation and Evaluation of Diclofenac Potassium loaded Agarose Beads.
Keywords:
Microsphere, Diclofenac potassium, Agarose, SEMAbstract
Controlled release technology has emerged to be an important area of research in the field of novel drug delivery system. Being a member of controlled release system, microspheres are very useful for achieving therapeutic response for improving patient compliance. Microspheres of diclofenac potassium were prepared by using cold gelation technique with the help of a biodegradable polymeragarose. Beads were prepared by dropping a hot aqueous agar solution in to a beaker containing a mixture of chilled light liquid paraffin and water. pH of water was adjusted 1.60 by adding concentrated hydrochloric acid to reduce the prior diffusion of diclofenac potassium. Drug release profile (in-vitro release), swelling index, particle size analysis, entrapment of drug into beads were investigated. Scanning electron microscopy (SEM) was carried out for characterisation of beads.
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